Comparative Analysis of Prevalence and Antibiotic Resistance in Vancomycin-Resistant Enterococcus from Clinical Samples – Demographics and Phenotypes

Background: Of all enterococci species, the most renowned clinically as multidrug-resistant pathogens are Enterococcus faecium and faecalis. Vancomycin-resistant (VRE) species principal cause of opportunistic hospital-acquired infections, due to numerous resistance mechanisms. Methods: In this study, prevalence antibiotic profiles VRE according clinical sources from three selected hospitals in Southwest-Nigeria were investigated. Altogether, 431 samples (urine, rectal, wound swabs - caesarian section (CS), automobile accidents, other skin lesions abrasions) collected Osun State, Nigeria. Established techniques employed for recovery screening while susceptibility tests carried out by disc diffusion technique. Results: 208 (48.3%) strains recovered which 85 (40.9%) VRE. E. predominated at 71.8% (61/85) faecalis 28.2% (24/85) determined phenotypic characterization. isolates exhibited 100%, 97.6%, 92.9% ampicillin, clindamycin, quinupristin-dalfopristin (Q/D) respectively. The least in-vitro was tigecycline (27.1%). None antibiotics 100% activity against isolates. vanA resistant phenotype prevalent 65.9%. study locations displayed higher levels than Multiple (MAR) indices ≥0.2, being multidrug-resistant. Conclusions: high rate along with level multidrug observed present is worrisome poses a continuous threat therapy illnesses triggered vancomycin perceived drug choice curb enterococcal infections.